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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMAD6 All Species: 18.18
Human Site: S320 Identified Species: 33.33
UniProt: O43541 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43541 NP_001136333.1 496 53497 S320 P G E F S D A S M S P D A T K
Chimpanzee Pan troglodytes XP_523105 496 53474 S320 P G E F S D A S M S P D A T K
Rhesus Macaque Macaca mulatta XP_001104638 454 49165 S278 P G E F S D A S M S P D A T K
Dog Lupus familis XP_544737 499 53465 S321 P G E F S D A S M S P D A T K
Cat Felis silvestris
Mouse Mus musculus O35182 495 53696 S321 P G E F S D A S M S P D A T K
Rat Rattus norvegicus O88406 426 46439 R258 L L L E P G D R S H W C V V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516238 280 31765 H113 P D T M K Q S H W C N V A Y W
Chicken Gallus gallus Q9W734 431 47806 D258 S D A S T S P D A V K R S H W
Frog Xenopus laevis NP_001091249 352 38824 G185 S R D M S K Q G H W C S V A Y
Zebra Danio Brachydanio rerio Q9I9P9 468 52435 P266 N H G M D L Q P V T Y S E P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42003 455 50486 H278 C R V G E V F H C N N N S V I
Honey Bee Apis mellifera XP_396816 251 28007 E84 W C T L A Y W E L G G R V G R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798238 371 42051 R204 D A T N G N R R H W C H V A Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 90.7 94.9 N.A. 93.3 42.5 N.A. 44.3 67.5 51 23.7 N.A. 22.5 29.2 N.A. 38.9
Protein Similarity: 100 99.4 90.9 95.7 N.A. 94.3 54.2 N.A. 49.7 73.1 58 39.9 N.A. 38.9 34.4 N.A. 50.2
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 13.3 0 6.6 0 N.A. 0 0 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 0 N.A. 20 13.3 13.3 13.3 N.A. 20 20 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 8 0 39 0 8 0 0 0 47 16 16 % A
% Cys: 8 8 0 0 0 0 0 0 8 8 16 8 0 0 0 % C
% Asp: 8 16 8 0 8 39 8 8 0 0 0 39 0 0 0 % D
% Glu: 0 0 39 8 8 0 0 8 0 0 0 0 8 0 0 % E
% Phe: 0 0 0 39 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 39 8 8 8 8 0 8 0 8 8 0 0 8 0 % G
% His: 0 8 0 0 0 0 0 16 16 8 0 8 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 8 8 0 0 0 0 8 0 0 0 39 % K
% Leu: 8 8 8 8 0 8 0 0 8 0 0 0 0 0 0 % L
% Met: 0 0 0 24 0 0 0 0 39 0 0 0 0 0 0 % M
% Asn: 8 0 0 8 0 8 0 0 0 8 16 8 0 0 0 % N
% Pro: 47 0 0 0 8 0 8 8 0 0 39 0 0 8 0 % P
% Gln: 0 0 0 0 0 8 16 0 0 0 0 0 0 0 0 % Q
% Arg: 0 16 0 0 0 0 8 16 0 0 0 16 0 0 8 % R
% Ser: 16 0 0 8 47 8 8 39 8 39 0 16 16 0 0 % S
% Thr: 0 0 24 0 8 0 0 0 0 8 0 0 0 39 0 % T
% Val: 0 0 8 0 0 8 0 0 8 8 0 8 31 16 0 % V
% Trp: 8 0 0 0 0 0 8 0 8 16 8 0 0 0 16 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 8 0 0 8 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _